Long-term prognosis in left ventricular non-compaction cardiomyopathy

Abstract Introduction Left ventricular non compaction (LVNC) cardiomyopathy is an often underdiagnosed disease characterized by a thickened myocardium with two-layered structure. Clinical presentations are very variable, ranging from apparent lack of functional anomalies to heart failure, arrhythmias and, in some cases, even ischaemic stroke. Despite great improvements diagnostic performance, there still wide evidence regarding prognosis and management affected patients. Purpose The aim the present study was investigate predictors cardiovascular death or cardiovascular-related hospitalization patients LVNC over long-term follow-up. Methods All consecutive definite diagnosis admitted Cardiomyopathy Clinic our institution Jan 2015 Dec 2020 were consecutively enrolled. Inclusion criteria age ≥18 years old made either MRI echocardiography. Exclusion life expectancy ≤1 year inability express informed consent for study. follwed-up every six months. primary endpoint composite unplanned hospitalization. Results Twenty-one (14 male, 40±17 years) meeting inclusion prospectively enrolled followed-up median five years. previous history supraventricular tachycardia at time more likely meet during follow-up (60% vs. 18%; p=0.048; Figure 1). On other hand, neither LVEF (measured echo CMR) nor status associated significantly increased risk (all p=NS). Other significant include OSAS (z2 = 4.158), active/previous smoking 6.279), ST-segment alterations 4.158). NC/C, as measured CMR, not predictor events (HR 0.18; 95% CI 0.31–1.08; Conclusions Our data show how, LVNC, tachycardias related worse outcomes their presence should prompt closer order detect possible adverse events. alterations, also poorer prognosis, but relevance be further assessed. Surprisingly, sample NC/C ratio outcomes; reason might that mortality hospitalizations resemble complex genetic molecular mechanisms differentiate them cardiomyopathies, paucity population prevents us making wider inferences. Funding Acknowledgement Type funding sources: None.